Is Nephrotic Syndrome Serious
Nephrotic Syndrome (NS) is a disease that affects the kidneys. It is completely associated with excessive loss of albumin in the urine, usually defined as more than 3.5g per day. Is Nephrotic Syndrome serious? How serious is it?
Nephrotic syndrome is characterized by high levels of proteinuria (secondary to podocyte injury or dysfunction), hypoproteinemia, and edema, and is associated with complex acquired hypercoagulopathy with a high risk (at least 25%) of life-threatening thrombotic complications.
Nephrotic syndrome develops when the glomeruli are damaged, and structures in the kidneys filter blood. This damage causes proteins in the blood, such as albumin, to leach into the urine, leading to increased protein excretion (proteinuria). Eventually, blood levels of albumin drop, which can cause fluid retention (edema) and renal dysfunction.
-Complications of Nephrotic Syndrome: loss of immunoglobulin in urinary protein increases susceptibility to infection. The balance of clotting factors in the blood can also be altered by this condition, increasing the risk of thrombosis in patients with the condition.
-Nephrotoxicity: the greater the protein loss in urine, the faster the kidney develops glomerulosclerosis and failure.
-It develops into chronic Kidney Failure and eventually uremia.
How serious are the symptoms of Nephrotic Syndrome?
The most common symptoms of Nephrotic Syndrome are swelling, weight gain, fatigue, blood clots and infection. Some people may develop kidney failure. Increased protein excretion can cause foamy urine.
Swelling - Swelling in people with nephrotic syndrome usually affects the inner lining of the eye socket and often causes swelling around the eyes when they wake up in the morning. Swelling of the feet or ankles can also occur after a period of sitting or standing.
Lipid - The concentration of lipids (cholesterol and/or triglycerides) in nephrotic syndrome can be greatly elevated. If sustained, this may increase the risk of coronary artery disease.
Thrombus - People with nephrotic syndrome have an increased risk of blood vessel or arterial clots. The clots in the veins can move to the lungs. This can be dangerous, even deadly.
Infections - People with severe nephrotic syndrome are at increased risk of infection, especially in children with minimal change disease, although the cause is unclear.
Kidney Failure - In some patients with nephrotic syndrome, renal function declines gradually, causing no symptoms in the early stages. However, as renal function continues to deteriorate, the symptoms of renal failure may develop, including shortness of breath, weakness and susceptibility to fatigue (anemia) and loss of appetite.
How should Nephrotic Syndrome be treated?
Proteinuria - ACE inhibitors or ARB are generally recommended to reduce protein loss in urine (proteinuria).
Edema - Nephrotic Syndrome patients often have leg swelling (edema) and abdominal effusion (ascites). Edema and ascites can get improved in people who follow a low-sodium diet and take "water pills" (diuretics).
High cholesterol - high cholesterol levels are common in patients with nephrotic syndrome. If nephrotic syndrome persists, treatment is needed to lower blood cholesterol. Most people are initially treated with cholesterol-lowering drugs called statins.
Thrombus - if a blood clot forms in the blood vessels, treatment may include blood thinners such as warfarin (coumarin) as long as nephrotic syndrome persists.
Now you have a specific understanding of how severe Nephrotic Syndrome is. If you are a Nephrotic Syndrome patient, please take your time to treat it actively. For more information on Nephrotic Syndrome treatment, please leave a message below or contact online doctor.
***Please seek professional medical advise for the diagnosis or treatment of any ailment, disease or medical condition. This article is not intended to be a substitute for the advice of a licensed medical professional.***