Treatment of Steroid-Resistant Nephrotic Syndrome

Treatment of Steroid-Resistant Nephrotic SyndromeSteroid-resistant Nephrotic Syndrome (NS) refers to the situation in which patients with Nephrotic Syndrome are ineffective after 8-12 weeks of steroid therapy with conventional dosage (prednisone 1 mg/kg.d), or the initial steroid therapy is effective, but the second use is ineffective after relapse. However, in focal segmental glomerulosclerosis (FSGS), most scholars believe that prednisone (1mg/kg.d) for 16 weeks without remission of Nephrotic Syndrome can be considered as steroid resistance. In children with minimal change disease, the incidence of steroid resistance is about 5%. Recurrent Nephrotic Syndrome refers to that the initial steroid treatment is effective, but the recurrence of Nephrotic Syndrome within 6 months after withdrawal is more than 2 times. Steroid dependence refers to that steroid treatment is effective, but once it is reduced or stopped, the disease relapses within 2 weeks.

For patients with steroid resistance, the following aspects of work must be done first:

(1) Make a clear diagnosis

For Nephrotic Syndrome patients with poor steroid effect, it is necessary to conduct renal biopsy to make a clear diagnosis. These patients' renal biopsy often indicates FSGS or early membranous nephropathy. At the same time, attention should be paid to excluding secondary causes such as tumors, diabetes, hepatitis-related glomerulonephritis and so on.

(2) Remove the infected lesions

Infection is an important cause of steroid resistance, frequent relapse and refractory treatment in patients with nephrotic syndrome. In addition to the obvious clinical symptoms such as respiratory tract infection and urinary tract infection, we should pay attention to some latent infection foci such as chronic pharyngitis, otitis media, sinusitis, toothbitis and so on.

(3) Compliance of patients

It is also a problem that should not be neglected whether patients take medicine according to the orders of doctors.

(4) Problems affecting drug absorption

Such as severe edema, severe gastrointestinal dysfunction and so on.

After discovering and removing the above factors which may affect the therapeutic effect of steroids, immunosuppressive drugs and treatment schemes, as well as other non-immunotherapy measures, are adjusted according to different pathological types to improve the state of steroid resistance and improve the remission rate of nephrotic syndrome. Besides, you can try a systemic Chinese Medicine Treatment, for example, the combination of Medicated Bath, Foot Bath, Enema Therapy and so on. This set of treatment can help counteract the side effects of western medicine. It can also help make internal environment good for kidney self-healing and other medication application. After a period of treatment, you can get a permanent control of the disease.

Now you know the treatment of steroid-resistant Nephrotic Syndrome. For more corresponding information, please leave a message below or contact online doctor.


***Please seek professional medical advise for the diagnosis or treatment of any ailment, disease or medical condition. This article is not intended to be a substitute for the advice of a licensed medical professional.***

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