Is Renal Biopsy A Must for Adult Nephrotic Syndrome

Renal Biopsy, Adult Nephrotic SyndromeIs renal biopsy a must for adult Nephrotic Syndrome?

Nephrotic syndrome is not the final diagnosis of the disease strictly. It is defined as massive proteinuria (proteinuria > 3.5g/day) and hypoalbuminemia (albuminuria < 30g/L). The etiology of nephrotic syndrome can be divided into two categories: primary and secondary. Generally speaking, the former is caused by the kidney itself, while the latter is caused by other systemic diseases affecting the kidney, such as hepatitis B, systemic lupus erythematosus and Diabetes Mellitus. Therefore, the treatment methods are quite different.

Children's nephrotic syndrome has a single pathological type, 90% of which are Minimal Change Disease (MCD). It can be treated by with steroids directly without renal biopsy.

However, adult nephrotic syndrome has a variety of pathological types, such as MCD, membranous nephropathy, focal segmental glomerulosclerosis (FSGS), IgA Nephropathy, etc. Different types of nephrotic syndrome have different treatment methods and prognosis. Even for the same pathological type, the severity of the lesion varies individually. Without renal biopsy, doctors can only make empirical judgments through clinical symptoms and examination results, and it is difficult to give precise and individualized treatment plans, so the curative effect can not be guaranteed. With the pathological results, the doctor can be more sure of the whole treatment process.

Is there a high risk of renal biopsy?

Are there any sequelae? Does it affect renal function? These problems are worrying for many kidney patients. Although biopsy is invasive, it is also a minimally invasive examination. At present, puncture instruments and puncture techniques have been very mature. Only a few dozen glomeruli are removed from 2-3 pieces of 2 cm long kidney tissues. Compared with more than 2 million human nephrons, puncture is insignificant, and it does not affect renal function, nor does it have a great impact on the body. On the contrary, if you don't follow the doctor's advice, blindly listen to rumors and refuse to biopsy, you may take a detour. Once you miss the best treatment opportunity, the kidney disease progresses to an irreversible stage, the treatment effect will be greatly discounted, and then it will be too late to regret.

The greatest risk of renal puncture is bleeding.

The incidence of microscopic hematuria is almost 100%. There is no need to be too nervous. It will disappear spontaneously in 1 to 2 days. If there are gross hematuria or even blood clots, severe low back pain, abdominal pain and other symptoms of perirenal hematoma, it needs to be evaluated and treated by doctors. Strictly according to the doctor's requirements, lying on the bed for 24 hours after puncture and not exerting on the waist can greatly reduce the occurrence of complications. We recommend that patients with nephrotic syndrome, in the absence of obvious bleeding tendency, isolated kidney, renal atrophy and other circumstances, can cooperate with the doctor's surgery so as to make the final treatment plan after renal biopsy.

Now you know whether it is necessary to do renal biopsy with adult Nephrotic Syndrome. For more information on Nephrotic Syndrome, please leave a message below or contact online doctor.


***Please seek professional medical advise for the diagnosis or treatment of any ailment, disease or medical condition. This article is not intended to be a substitute for the advice of a licensed medical professional.***

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