Two Key Points in the Treatment of Children with Nephrotic Syndrome

Two Key Points in the Treatment of Children with Nephrotic SyndromeChildren with Nephrotic Syndrome often suffer from proteinuria of more than 3.5g/24h and hypoproteinemia of less than 30g/L. Ninety percent of children with nephrotic syndrome are minimal change disease. Most of them have a good prognosis. And about 10% of children suffer from renal failure.

24-hour urinary protein in children with nephrotic syndrome is often very high, sometimes reaching more than 10g. However, the decrease of urinary protein is not difficult. Most patients are sensitive to glucocorticoids, and the urinary protein will be relieved after one month of steroid application.

There are two aspects that concern patients and their families:

First, the effect of steroids is not obvious for a small number of children with nephrotic syndrome.

This phenomenon does not often occurs in minimal change disease (MCD). In some cases, renal biopsy shows MCD firstly, but after a period of time, the pathological type changes. The most common pathological change of MCD is focal segmental glomerulosclerosis (FSGS), which leads to steroid inefficiency. It may also be a misdiagnosis of renal biopsy. There are some pathological similarities between MCD and FSGS and some mesangial proliferative nephritis. This condition often requires a second renal biopsy to confirm the diagnosis.

Second, proteinuria recurs when steroids are reduced or discontinued.

When exogenous steroids enter the human body, the human body will reduce its own hormone secretion to adapt to the environment of a large number of steroids. When the exogenous steroid decreases, the hormone secreted by oneself can not keep up with. As a result, the inflammatory reaction and urinary protein will come back, as if the human body can not do without steroids, showing steroid-dependent nephrotic syndrome.

Steroid-dependent nephrotic syndrome in children should reduce steroids very slowly, and at the same time combine Traditional Chinese Medicine (TCM) to reduce the relapse rate. The commonly used TCM therapies include Foot Bath, Medicated Bath, Steam Therapy, Acupuncture, etc.

Those therapies can eliminate waste products and extra fluid from the blood to make internal environment clean and reduce the workload of kidneys. They can also restore the balance of anti-inflammatory cytokines and pro-inflammatory cytokines to reduce renal inflammation and control the disease from getting worse. Moreover, they can dilate blood vessels and remove stasis to improve blood circulation and increase blood flow into kidneys so that enough essential elements such as oxygen, nutrients and active ingredients of medicine can be transported into nidus to speed up kidney recovery.

After a short period of treatment, swelling, proteinuria and some other symptoms will be relieved greatly. After a long period of treatment, Nephrotic Syndrome will be under control.

Now you know the two key points in the treatment of children with Nephrotic Syndrome. If you still have any other questions, please leave a message below or contact online doctor.


***Please seek professional medical advise for the diagnosis or treatment of any ailment, disease or medical condition. This article is not intended to be a substitute for the advice of a licensed medical professional.***

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