Hyperlipidemia in Nephrotic Syndrome

Hyperlipidemia in Nephrotic SyndromeBesides massive proteinuria and heavy swelling, hyperlipidemia is another typical symptom of Nephrotic Syndrome. In this article, let’s have a quick look at its cause and treatment. Hope it can help you.

What causes hyperlipidemia in Nephrotic Syndrome?

Blood lipids mainly include cholesterol, triglyceride and phospholipids.

Lipids bind to proteins in plasma and exist and transport in the form of lipoproteins.

There are five types of lipoproteins: chylous microparticles (CM), very low density lipoprotein (LVDL), low density lipoprotein (LDL), medium density lipoprotein (1DL), and high density lipoprotein (HDL).

The mechanism of hyperlipidemia in nephrotic syndrome is not very clear. At present, it is believed that the decrease of colloid osmotic pressure caused by hypoproteinemia and/or the loss of a regulatory factor in urine may increase the synthesis of cholesterol, triglyceride and lipoprotein in the liver.

Furthermore, in nephrotic syndrome, the activity of lipoprotein lipase decreases, resulting in lipid clearance obstacles.

At the same time, in experimental nephrotic syndrome, the activity of lysolecithin acyltransferase is increased, which could catalyze the acetylation of lysolecithin into lecithin and increase the level of blood lecithin. This leads to hyperlipidemia in nephrotic syndrome.

Treatment for hyperlipidemia in Nephrotic Syndrome


Patients with hyperlipidemia should strictly control their fat intake; adjust the type of fat, to replace saturated fatty acids with polyunsaturated fatty acids; eat more vegetable foods rich in dietary fiber; obese people should control their weight; low cholesterol diet, daily cholesterol intake should be controlled below 200 mg, avoid using food with high cholesterol content such as animal viscera.

Suitable food:

1. Vegetables rich in dietary fiber (such as celery, leek, rape), coarse grains, etc.

2. Deep-sea fish rich in polyunsaturated fatty acids;

3. Dairy and dairy products, beans and soybean products;

4. To choose soybean oil and salad oil.

5. If deep-sea fish oil is supplemented separately, vitamin E should be added to prevent lipid peroxidation.

Avoid (less) using food:

1. Animal fat, animal oil;

2. Animal viscera (especially brain), yolk, fish seeds, crab seeds, clams and shellfish with high cholesterol content.

-Medical treatment

Western medicine such as enteric-coated aspirin, dipyridamole and lipid-lowering drugs such as Lipingzhi can be used as therapeutic drugs. Chinese medicine such as Salvia miltiorrhiza or Ginkgo biloba extract can also be used to activate blood circulation and remove blood stasis, regulate qi and relieve pain.

Through dietary and drug adjustments, blood lipids should be able to return to normal. For more information on Nephrotic Syndrome treatment, please leave a message below or contact online doctor.


***Please seek professional medical advise for the diagnosis or treatment of any ailment, disease or medical condition. This article is not intended to be a substitute for the advice of a licensed medical professional.***

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