How to Improve Acidosis for Kidney Failure Patients

sodium bicarbonate, acidosis, kidney failureAlmost every patient with chronic Kidney Failure has a complication: acidosis. That is, blood lacks bicarbonate (HCO 3-) and tends to be acidic.

What is acidosis and what harm is it?

Renal tubules have the ability to reabsorb bicarbonate. When renal tubules are damaged (at this time, most of them have renal failure), serious loss of bicarbonate will lead to acidosis.

Patients with renal failure need regular blood sampling to check electrolytes and kidney function. Hydrogen carbonate (HCO 3-), sometimes called carbon dioxide (CO2) and carbon dioxide binding force, on the test sheet are indicators for monitoring acidosis.

The normal value is above 22 mmol/L. If it is lower than 22 mmol/L, acidosis can occur.

The harm of acidosis:

1. Stimulation of glomerular endothelial cells, mesangial cells, proximal convoluted tubules, medullary loops, distal convoluted tubules and so on can decrease renal function.

2. Ammonia production increases, leading to renal fibrosis and atrophy.

3. When acidosis occurs, the body will quickly decompose the protein in the body, resulting in malnutrition. Because patients with renal failure need to reduce protein intake, malnutrition will be more difficult to improve.

If the concentration of bicarbonate in blood can be increased, the adverse environment of kidney can be improved, thus protecting kidney function and delaying the progress of kidney function.

The fastest way to correct acidosis is Dialysis, but that's a helpless move that has progressed to uremia. Drug therapy is the best choice when renal function is still acceptable.

How to improve acidosis?

The best way is to take oral alkali. The commonly used alkali agents are sodium citrate and sodium bicarbonate. The most commonly used method in clinic is oral sodium bicarbonate (baking soda) to increase the concentration of bicarbonate.

Sodium bicarbonate tablets are very cheap, so some patients do not care about it, and think it is optional, but in fact its role can not be ignored.

JASN, the journal with the highest impact factor in the field of kidney disease, published a study in which 134 patients with renal failure were divided into two groups: those who ate sodium bicarbonate and those who did not. Two years later, it was found that those who ate sodium bicarbonate had lower serum creatinine and better renal function.

In addition to renal failure, studies have shown that sodium bicarbonate can also reduce the risk of progression in patients with nephritis and Nephrotic Syndrome with normal renal function, but the recommended grade is lower.

In conclusion, sodium bicarbonate can increase the concentration of bicarbonate in the blood of patients with impaired renal function and elevated serum creatinine, thus protecting renal function.

Finally, sodium bicarbonate is not suitable for everyone. Kidney patients must take medicine under the guidance of doctors. For more information on kidney failure treatment, please leave a message below or contact online doctor.


***Please seek professional medical advise for the diagnosis or treatment of any ailment, disease or medical condition. This article is not intended to be a substitute for the advice of a licensed medical professional.***

Share Link

Leave A Message

Hope the above information is helpful for you. If you have any questions on it, you can leave a message below. We have doctors to contact you and give you free online guidance.