Stem Cell Therapy Might Help Renal Transplant Patients
According to a new study from the Stanford University School of Medicine, a Stem Cell Therapy given shortly after a kidney transplant allows some patients to get off the medicines meant to keep their body from attacking the new organ.
Kidney transplants are common in the world and while they can greatly improve quality of life for someone with kidney failure, post-transplant life still carries challenges.
A lifelong drugs are required to help kidney transplant patients avoid rejection of the new kidney. The powerful medicines have serious side effects, too, like an increased risk for type 2 diabetes, certain cancers, heart disease and infection. Although some immune-suppressing drugs can protect kidney, they can contribute to damage and the eventual loss of the transplanted kidney.
In a survery, there are data from 12 kidney transplant patients who received a new kidney from a perfect match, typically a sibling. Eight of the patients, who ranged in age from 22 to 68 and underwent the setm cell therapy, have now avoided immune-suppressing drugs for at least one year. For some, the drug-free stretch has lasted as long as three years.
A researcher did a research in mice, involving a combination of radiation, donor stem cells, and antibodies.
Following transplant surgery in the hospital, the kidney recipient receives radiation targeted at the lymp nodes, spleen and thymus gland to weaken the immune system. The antibodies are given too. Ten days later, the organ donor’s stem cells, called hematopoietic progenitor cells, which form blood and immune-system cells-are infused into the new kidney patient on an outpatient basis. Gradually the donors stem cells differentiate and join with the transplant patients own immune system, making it more receptive to the donor kidney.
A couple of immunosuppressant drugs are given early. But the patient avoids them if no signs of rejection appear within the early months.
The goal of this research was to try and eliminate the use of lifelong drugs and keep the transplant. The problem of keeping people on chronic immune-suppressing drugs is very significant. To have the opportunity to use stem cells as a way to overcome that is very creative and based on really sound science.
In summary, Stem Cell Therapy might help kidney transplant patients. If you want to learn more information, you can leave a message below or consult our online doctor directly. We will reply you as soon as possible.
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