Four Common Clinical Manifestations of IgA Nephropathy

Four Common Clinical Manifestations of IgA NephropathyClinical manifestations of IgA Nephropathy are diverse. Here we list four common manifestations. Do you have any of them? Now read on to learn more information.

1. Hematuria

80%-90% of patients with lgA Nephropathy show hematuria, which can be microscopic hematuria, only found in physical examination or urinalysis of other diseases, or it can also be manifested as recurrent gross hematuria. The gross hematuria lasts for 1 to 3 days. In some cases, it even lasts for 1 week or several weeks, and then turns to continuous microscopic hematuria or returns to normal. Moreover, some cases may be accompanied by low back pain, abdominal pain or frequent urinary urgency. The interval of gross hematuria episodes gradually prolongs, and eventually no recurrence occurs.

2. Nephrotic Syndrome

10%-20% of IgA Nephropathy is characterized by massive proteinuria, hypoproteinemia, hyperlipidemia and edema of varying degrees. Most of them are accompanied by microscopic or gross hematuria. Most of the children with IgA Nephropathy are misdiagnosed as primary Nephrotic Syndrome, which is usually diagnosed by renal biopsy because of no or partial response to corticosteroid therapy.

3. High blood pressure

Hypertension in early stage of IgA Nephropathy is not common (< 5%-10%). With the prolongation of the course of disease, the incidence of hypertension in IgA nephropathy patients over 40 years old is 30%-40%. A few patients may have malignant hypertension, and the prognosis of patients with persistent hypertension is poor. Within 10 years, 10% to 20% of IgA nephropathy patients develop chronic renal failure (CRF), and it can be roughly estimated that 1% to 2% of IgA nephropathy patients develop CRF every year since the diagnosis of IgA nephropathy is established.

4. Acute nephritic syndrome

10%-15% of IgA nephropathy patients present with acute nephritic syndrome such as hematuria, proteinuria, hypertension, reduced urine volume and mild edema. A few patients with IgA nephropathy (< 10%) may be complicated with acute renal failure (ARF). Most of them suffer from gross hematuria and often have severe low back pain. Renal biopsy can show acute tubular necrosis, extensive erythrocyte tubular type and partial crescent formation (< 50% glomeruli). ARF in these patients is mostly reversible, and in a few patients with diffuse crescent formation, renal function deteriorates progressively, so they often need dialysis treatment, and kidney function is difficult to recover.

Do you have the above four common clinical manifestations of IgA Nephropathy? Have you received any effective treatment to help you bring them under control? If not, you can try Chinese Medicine Treatment. For more information on IgA Nephropathy treatment, please leave a message below or contact online doctor.


***Please seek professional medical advise for the diagnosis or treatment of any ailment, disease or medical condition. This article is not intended to be a substitute for the advice of a licensed medical professional.***

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