Diabetes Mellitus Patients Should Prevent Microangiopathy

Diabetes, MicroangiopathyMicrovasculature generally refers to the capillary and microvascular network with a diameter of less than 100 microns between the arterioles and veins. It is the most basic structural unit in human blood circulation, accounting for 90% of the whole blood vessels, and is an important part of maintaining metabolism.

Microvascular basement membrane thickening is an early manifestation of diabetic microangiopathy. When the basement membrane is seriously thickened, the involved microvessels may be partially or totally blocked, resulting in tissue hypoxia so that the pathological changes continue to aggravate. Endothelial cell injury also plays an important role in the pathogenesis of microangiopathy. It can lead to blockage of blood flow and hypoxia of tissues.

Microvascular disorders in diabetic patients

Microvascular hemodynamic changes are the early changes of diabetic microvascular disease, but also an important initiating mechanism. In the early stage of diabetes mellitus, whether in kidney, retina or other peripheral tissues, blood flow increases and hyperperfusion occurs first. This abnormal hemodynamics can lead to increased microvascular permeability, and macromolecular proteins can be infiltrated and deposited in the wall of microvessels.

Changes of physical and chemical characteristics of microcirculation blood in diabetic patients

The blood of diabetic patients presents hypercoagulable state. When glycometabolism is disturbed, the agglomeration of erythrocyte is enhanced, the function of releasing oxygen is abnormal, the platelet adhesion is high and the mechanism of anticoagulation is abnormal, which makes the whole blood viscosity increase, blood flow slow and stagnant, and causes the stenosis of lumen and microcirculation disturbance, all of which promote the occurrence of microangiopathy.

Diabetic microangiopathy is systemic, so it is easy to cause widespread harm to the body.

In recent years, it has been found that the microcirculation of diabetic patients has different degrees of abnormalities, mainly manifested in retina, kidney, myocardium, nerve tissue and toe lesions. Diabetic retinopathy, Diabetic Nephropathy and diabetic peripheral neuropathy are the main clinical manifestations.

When diabetic retinopathy occurs, microangioma, cotton-like spots, hemorrhage, rigid exudation, neovascularization, and fibrosis can cause visual impairment, and even retinal detachment, leading to blindness. Diabetic Nephropathy occurs with proteinuria, abnormal glomerular filtration, diffuse and nodular glomerulosclerosis, or complete vitreous changes, leading to nephropathy, renal failure and death due to uremia. When microangiopathy accumulates in the nervous system, the vessels that nourish the nerves become extensively sclerotic, causing diabetic neuropathy, such as damage to the peripheral nervous system.

In the early stage of diabetes, when the disease is not well controlled, microvascular changes may occur, and metabolic abnormalities disappear after correction, which is reversible. Compound Danshen Dropping Pills, a modern Chinese Medicine Treatment, can improve microcirculation disorders by multiple targets. The water-soluble components of Salvia miltiorrhiza can remove peroxide, inhibit the expression of adhesion molecules in vascular endothelial cells, resist albumin exudation and platelet aggregation. And Panax notoginseng can inhibit mast cell degranulation, platelet aggregation and leukocyte adhesion. It has a good preventive and therapeutic effect on diabetic microangiopathy, can significantly improve the retinal microcirculation of patients, prevent the decline of vision and blindness; and plays a role in different stages of the development of diabetic nephropathy; it also has a good effect on the improvement of symptoms of diabetic peripheral neuropathy, and brings good news to the majority of diabetic patients. For more information on diabetes treatment, please leave a message below or contact online doctor.


***Please seek professional medical advise for the diagnosis or treatment of any ailment, disease or medical condition. This article is not intended to be a substitute for the advice of a licensed medical professional.***

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