How to Reverse High Serum Creatinine Level

How to Reverse High Serum Creatinine Level

Can you only wait for Dialysis when your creatinine level is high? How to reverse High Serum Creatinine Level? Here are four ways to help you.

Creatinine is an indicator to reflect kidney function. When kidney function gets restored, serum creatinine level will go down naturally. There are indeed many ways to lower creatinine level, but they do nothing to improve renal function. Therefore, in this article, we will teach you how to restore renal function so as to reduce creatinine.

1. Immunosuppressants or steroids to reduce creatinine level

Applicable to patients with Nephrotic Syndrome, Lupus Nephritis and so on.

Nephrotic Syndrome patients with heavy edema often have sudden elevation of creatinine level in a short time. With type Ⅳ Lupus Nephritis, biopsy pathologic examination will find more than half of the glomeruli are involved, and it is easy to enter the active stage (glomerular lesions are aggravating, and renal tubular interstitial become fibrosis and atrophy).

For the above patients, it is mainly to treat the primary disease. After making a clear diagnosis, immunosuppressants (e.g., prednisone, cyclophosphamide, tacrolimus, etc.), can be used to control the underlying disease, restore kidney function and normalize creatinine level.

At the same time, diuresis, hypotension, anticoagulation, lipid lowering and other treatments are performed as appropriate.

2. Anti-hypertensive drugs to reduce creatinine level

Applicable to kidney patients with high blood pressure.

Most kidney patients do not have the habit of measuring blood pressure at home everyday, so sometimes they do not know their blood pressure has elevated. At such a case, it is likely for serum creatinine level to go up. Especially for patients whose blood pressure is not under control, they are prone to high blood pressure and high creatinine level.

In such patients, creatinine levels drop after blood pressure is controlled with antihypertensive drugs. Blood pressure standards are:

When albuminuria is less than or equal to 30 mg/day, the blood pressure should be controlled to be less than or equal to 140/90mmhg

When albuminuria > 30 mg/day, blood pressure should be controlled at no more than 130/80mmhg.

The first choice drug to lower blood pressure is ACEI or ARBs. When a single anti-hypertensive drug fail to achieve blood pressure targets, or wen the initial systolic blood pressure is more than 150, two antihypertensive drugs can be combined: ACEI/ARBs + CCBs. Refractory hypertension can be treated with a combination of ACEI/ARBs + CCBs + diuretics.

3. Anti-infective drugs to reduce creatinine level

Applicable to kidney patients with infections

Infection is the first cause of acute kidney injury, and respiratory tract infection, digestive tract infection, urinary tract infection is the most common cause of creatinine elevation.

If you have a fever, sore throat, abdominal pain, diarrhea, frequent and urgent urination, skin infection and other diseases, you should go to the hospital in time for treatment. The use of antibiotics and other anti-infection drugs to control the infection can help bring blood creatinine level down.

4. Fluid-supplement therapy to reduce creatinine level

Applicable to kidney patients with dehydration.

Dehydration often occurs in excessive sweating, high fever, bleeding, vomiting and diarrhea.

The kidney is a mass of capillaries that withers without a blood supply. When the body loses water, blood volume decreases, resulting in kidney ischemia, and then kidney function will decline. Decreased blood supply can also lead to decreased kidney detoxification so that creatinine level increases.

According to different conditions, glucose, normal saline, drinking water and other fluid-supplement therapy can be used, which can help normalize creatinine level.


Patients with hyperglycemia, hyperuricemia and hyperlipidemia as the main pathogenic factors also have corresponding methods of creatinine lowering, which are not described in this paper.

For acute kidney injury patients, it is to treat the root cause, and then serum creatinine level can be fully recovered. For Chronic Kidney Failure patients, there are more factors to consider, such as potassium, sodium, calcium chloride and other blood electrolytes, anemia, and acidosis, and treatment methods will also involve intestinal detoxification, skin detoxification, etc., thereby it is more difficult to lower creatinine level.


***Please seek professional medical advise for the diagnosis or treatment of any ailment, disease or medical condition. This article is not intended to be a substitute for the advice of a licensed medical professional.***

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