Six Drugs for Lowering Proteinuria

Six Drugs for Lowering ProteinuriaUrinary protein, as the most common factor leading to the progress of Chronic Kidney Disease (CKD), is of great significance to reduce it to 0.5g/24h. The following drugs have definite hypoproteinuric effects.

1. Glucocorticoids

At the beginning of the 20th century, immunology developed fiercely. It was found that nephritis was closely related to immunity. Kidney inflammation was caused by immune inflammation.

In 1948, synthetic glucocorticoid drugs came out, and the remarkable effect of steroids on rheumatic immune diseases won it the Nobel Prize.

Steroids have immunosuppressive effect, so can kidney patients use steroids to inhibit kidney inflammation and reduce urinary protein?

It is true that steroids are effective in most kidney diseases. Steroids were then used to treat kidney disease and inhibit the immune inflammation of the kidney. For more than half a century, glucocorticoid has been the mainstay of chronic kidney disease treatment, until now.

2. Immunosuppressants

Since the 1950s and 1960s, various immunosuppressive agents have emerged: tacrolimus, cyclophosphamide, mycophenolate mofetil, cyclosporine, leflunomide, Tripterygium wilfordii polyglycosides and so on.

Most of these immunosuppressants have stronger immunosuppressive effects than steroids. Immunosuppressive agents can be used to treat nephropathy when steroid therapy is ineffective.

3. ACEIs

In 1981, captopril, the first ACEI drug, was introduced. Because of many indications, good effect of lowering blood pressure and little side effects, it makes the world admire.

ACEI drugs such as captopril were authoritatively recommended by American and European guidelines, which opened the "golden decade" of ACEI drugs until the emergence of ARB drugs.

These drugs were originally developed as antihypertensive drugs. In the years after their advent, it was found that ACEI could also alleviate the immune inflammation of the kidney, thus playing a dual effect of lowering blood pressure and proteinuria, and becoming a first-line drug for the treatment of kidney disease.

4. ARBs

In 1994, losartan, the first ARB drug, was introduced. Both ARBs and ACEI belong to angiotensin inhibitors and have similar mechanisms of action. Their antihypertensive and antiprotein effects are comparable.

ARB has a more significant advantage than ACEI: no side effect of cough. It is evident in our country that dry cough is more common among East Asians after taking ACEI, accounting for nearly half of them. In recent years, the market share of ARBs has surpassed that of ACEI.

5. Spironolactone

Spironolactone, like ARBs and ACEI, is also a kind of antihypertensive drug. Diuretic antihypertensive drug and antiproteinuric mechanism are similar to that of ARBs and ACEI. It can be used for patients with mild to moderate proteinuria.

6. Statins

For example, simvastatin, pravastatin, rosuvastatin, fluvastatin, atorvastatin and lovastatin are suitable for hyperlipidemia and can reduce cholesterol and triglyceride. However, statin not only reduces lipid, but also reduces urinary protein in patients with chronic kidney disease.

Now you know the six kinds of drugs for lowering proteinuria. Have you taken any of them? If all of them are ineffective, you can try systemic Chinese Medicine Treatment. After about one month’s treatment, proteinuria will be reduced or even become negative. For more information on CKD treatment, please leave a message below or contact online doctor.


***Please seek professional medical advise for the diagnosis or treatment of any ailment, disease or medical condition. This article is not intended to be a substitute for the advice of a licensed medical professional.***

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