4 Causes for Tuberculosis In CKD Patients
The link between chronic kidney disease (CKD) and tuberculosis (TB) has been known for more than 40 years, but little is known about the interaction between these two diseases. Why are Chronic Kidney Disease (CKD) vulnerable to tuberculosis?
Clinically, patients with CKD and dialysis are at increased risk of tuberculosis infection, and the prevalence rate of tuberculosis is 6-30 times that of normal people.Possible reasons include:
The decrease of GFR can increase the risk of infectious disease because the decrease of CKD and GFR results in the retention of metabolic wastes and deficiency of some useful substances so as to cause immune cell dysfunction. In this condition, patient’s immune will decrease including granulocytopenia, decreased phagocytic function of monocytes/macrophages, functional impairment of antigen presenting cells, decreased number of B cells, decreased ability to produce antibodies and enhanced T cell apoptosis. Decreased immunity in CKD with/without dialysis and kidney transplant patients is the risk factor for tuberculosis.
Use of corticosteroids and immunosuppressants
High doses of corticosteroids and immunosuppressants are often required for the etiology of CKD, such as some autoimmune diseases or primary glomerular diseases. The immunosuppressive effect of these drugs increases the risk of TB infection. Transplant recipients also received anti-rejection treatment that increased their risk of TB by 3-24 times..
Deficiency of 25-Hydroxyvitamin D3
Patients in CKD stage 3-5 often have deficiency of 25-Hydroxyvitamin D3, which results in functional impairment of monocytes. Its ability to synthesize antimicrobial peptides that are destructive to mycobacterium tuberculosis is greatly reduced.
Patients with inadequate dialysis may have pulmonary edema, protein energy expenditure (PEW), anemia, etc., all of which are susceptible factors to tuberculosis.
When you have kidney disease, you should take active treatment. In early stage, it can be reversed. Here we recommend a systematic Chinese Medicine Treatment including Micro-Chinese Medicine Osmotherapy, Medicated Bath, Medicated Foot Bath, Mai Kang Mixture, Steaming Therapy, Enema Therapy and Moxibustion Therapy, etc. Chinese medicines first cleanse your blood to give you a clean blood environment. Then Chinese medicines can arrive at kidney lesion directly to repair kidney damage and improve renal function through dilating blood vessels, improving blood circulation, degrading extracellular matrix and providing nutrients. In this way, kidney disease can be treated well and its complications including tuberculosis can be avoided.
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***Please seek professional medical advise for the diagnosis or treatment of any ailment, disease or medical condition. This article is not intended to be a substitute for the advice of a licensed medical professional.***