What Causes Renal Osteopathy
Renal osteopathy causes the depletion of bone minerals. It is the pathological state of the bones and can be found in patients on regular dialysis. The disease is also called mineral and bone disease.
What causes renal osteopathy?
People with Chronic Kidney Disease sometimes find that their bones become weaker and thinner - more painful or more prone to fractures - because of the loss of minerals. The most common causes of renal osteopathy are:
The balance between two important minerals in the body (calcium and phosphate) changes, leading to the loss of calcium in bones.
*Calcitriol is secreted from vitamin D by normal kidneys.
*Because the kidneys do not produce normal amounts of calcitriol, kidney diseases usually lead to a lack of calcitriol.
*Lack of calcitriol in the blood can hinder the absorption of calcium in intestinal digestive food.
*Low levels of calcitonin increase parathyroid hormone levels, which remove calcium and phosphorus from the blood, leading to renal osteopathy.
Four small glands (parathyroid glands) that help regulate calcium in the body become overactive.
*Renal osteopathy is often found in patients with hyperparathyroidism.
*Hyperparathyroidism leads to hyperphosphatemia and hypocalcemia.
-Low vitamin D
The way the body uses vitamin D changes. Vitamin D is a mineral that is important for healthy bones.
*Both cases are due to reduced phosphate excretion in the affected kidneys.
*Low vitamin D levels are also due to the inability of affected kidneys to convert vitamin D into calcitriol, leading to further hypocalcemia.
-Loss of magnesium
*The excretion of high magnesium leads to low blood magnesium levels and high parathyroid hormone secretion.
*Excessive parathyroid hormone can lead to hypocalcemia, which is caused by the demineralization of calcium in bone.
Each of the four types of bone disease affects bones for different reasons:
*Most foods contain phosphates, and what the body does not need is usually removed by the kidneys. When your kidney stops working properly, phosphate may accumulate in your blood. Too much phosphate in the blood can lead to calcium loss in bones, which weakens them. Eating low-phosphate foods helps prevent phosphate from accumulating in the blood. You may also need to take a drug called phosphate binder, which helps prevent phosphate from being absorbed from the food you eat.
*Because when your kidney is no longer able to remove it, phosphate will stay in your body, and the four small glands in your neck (parathyroid glands) become too active. When this happens, calcium is removed from bones over a long period of time, causing them to weaken. Usually, by changing dialysis treatment, low phosphoric acid diet and taking certain drugs (such as calcium and vitamin D) can help solve this problem. Surgery sometimes requires removal of some of these glands.
*Vitamin D is an important vitamin that affects your calcium balance. Usually, vitamin D and vitamin and mineral supplements in the foods you eat are changed by the kidneys into "active" forms that can be used by the body. If your kidneys fail, they can't do this important job anymore. Fortunately, the active form of vitamin D can be used as a drug and your doctor can prescribe it for you if necessary. (Overall, patients with kidney disease should avoid using over-the-counter vitamin D supplements. Please consult your doctor about supplements that are suitable for you. The vitamin D content in the food you eat is not a problem.)
These are the causes of renal osteopathy. If you have any problems, you can consult our professional doctor to provide timely guidance or treatment plan.
***Please seek professional medical advise for the diagnosis or treatment of any ailment, disease or medical condition. This article is not intended to be a substitute for the advice of a licensed medical professional.***